mProX™ Human CAMK1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1047	Magic™ Human CaMK1α(CAMK1) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

CAMK1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

RAW 264.7; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Related Diseases

Among its related pathways are Transmission across Chemical Synapses and Activation of NMDA receptors and postsynaptic events.

Gene ID

8536

UniProt ID

Q14012

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The enzyme known as calcium/calmodulin-dependent protein kinase type 1 is encoded by the CAMK1 gene in humans. Numerous tissues express calcium/calmodulin-dependent protein kinase I, which is a part of a cascade of calmodulin-dependent protein kinases. By binding to the enzyme, calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I. Additionally, calcium/calmodulin-dependent protein kinase I kinase indirectly encourages the phosphorylation and synergistic activation of the enzyme. The customized CAMK1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Patricia

I am truly impressed with the performance of this CAMK1 cell line and the professionalism of Creative Biolabs. I highly recommend it to anyone. Dec 29 2022

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chat Deborah

I purchased the CAMK1 KD cell line from Creative Biolabs. The provided documentation was comprehensive and helped me optimize my assay conditions. May 26 2023

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 CaMK1 plays a role in IFN-β production.

IV or I and IV siRNAs were transfected into RAW cells. Western blotting was used to identify each CaMK isoform's expressions after 48 hours.

Ref: Ma, Lijuan, Seon-Ju Kim, and Kwon Ik Oh. "Calcium/calmodulin-dependent protein kinase is involved in the release of High Mobility Group Box 1 via the interferon-β signaling pathway." Immune network 12.4 (2012): 148-154.

Pubmed: 23091438

DOI: 10.4110/in.2012.12.4.148

Research Highlights

The results provide a molecular basis for the activation of mitophagy: release of calcium from the mitochondria causes CAMK1 to phosphorylate threonine 177, which precedes PINK1's phosphorylation at serine 228. This phosphorylation of serine 65 on PARK2 attracts PARK2 and initiates mitophagy.
Yang, Jie, et al. "Pitavastatin activates mitophagy to protect EPC proliferation through a calcium-dependent CAMK1-PINK1 pathway in atherosclerotic mice." Communications Biology 5.1 (2022): 124.
Pubmed: 35145192 DOI: 10.1038/s42003-022-03081-w

The results showed that CAMK1 had predictive value for PC patients, indicating that CAMK1 might play a unique role in PC patients and be a potential marker for examining the clinical prognosis of PC.
Lei, Yangyang, et al. "Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer." Journal of Cellular and Molecular Medicine 25.2 (2021): 1198-1206.
Pubmed: 33342045 DOI: 10.1111/jcmm.16188