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  • mProX™ Human BCR Stable Cell Line

    [CAT#: S01YF-1023-PY147]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    Kinase Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Leukemia, Chronic Myeloid; B-Lymphoblastic Leukemia/Lymphoma With T(9;22)(Q34.1;Q11.2)
    Gene ID
    Human:613
    UniProt ID
    Human:P11274

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Breakpoint Cluster Region (BCR) gene plays a pivotal role in cellular signaling and is most notably recognized for its association with the Philadelphia chromosome, a translocation between chromosomes 9 and 22. This translocation results in the BCR-ABL fusion gene, which is implicated in several types of leukemia, including chronic myeloid leukemia (CML). The BCR-ABL protein has constitutive tyrosine kinase activity, leading to uncontrolled cell proliferation. Research into BCR has paved the way for targeted therapies, such as tyrosine kinase inhibitors, which have revolutionized the treatment of CML and improved patient outcomes significantly.

    Protocols

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    Customer Reviews

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    FAQ

    chat Alex Davis (Verified Customer)

    What is the significance of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia? Nov 24 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    BCR-ABL tyrosine kinase inhibitors, like STI571, have shown significant antileukemic activity and are well-tolerated in chronic myeloid leukemia. Nov 24 2021

    chat Peyton Davis (Verified Customer)

    How does BCR-ABL gene mutation or amplification affect cancer therapy resistance? Jul 19 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Drug resistance in cancer therapy is often associated with the reactivation of BCR-ABL signal transduction. Jul 19 2020
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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