mProX™ Human AURKC Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Embryonic development is compromised in Aurkc−/− mice.
Given that mice devoid of Aurkb reach the blastocyst stage of development, it is probable that AURKC is involved in the initial cell divisions of the embryo.
Ref: Schindler, Karen, et al. "Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development." Proceedings of the National Academy of Sciences 109.33 (2012): E2215-E2222.
Pubmed: 22778418
DOI: 10.1073/pnas.1120517109
Research Highlights
The development of specific inhibitors of AURKC protein binding, which could result in additional advancements in the treatment of breast cancer, is facilitated by the small-molecule inhibitor AKCI.
Han, Eun Hee, et al. "A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells." Oncotarget 8.41 (2017): 69691.
Pubmed:
29050234
DOI:
10.18632/oncotarget.18883
AURKC, a member of the Aurora kinase gene family, is either modestly or suppressed in most somatic cells, but it is strongly expressed in the testis. Human malignancies have been shown to express AURKC differently, yet little is known about the underlying mechanisms causing this variation in expression.
Fujii, Satoshi, et al. "Regulation of AURKC expression by CpG island methylation in human cancer cells." Tumor Biology 36 (2015): 8147-8158.
Pubmed:
25990457
DOI:
10.1007/s13277-015-3553-5
