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    mProX™ Human ATP2B2 Stable Cell Line

    [CAT#: S01YF-1023-PY258]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;MDA-MB-231
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research
    Related Diseases
    Deafness, Autosomal Dominant 82; Deafness, Autosomal Recessive 12
    Gene ID
    Human:493
    UniProt ID
    Human:P23634

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ATP2B2, a gene involved in calcium signaling, has been studied in various contexts. In epilepsy, the expression of ATP2B2 and other related genes was found to be dysregulated in patients, suggesting their potential as biomarkers for the condition. In neurodevelopmental disorders, de novo variants in ATP2B2 were identified as a cause of variable symptoms such as dystonia, ataxia, intellectual disability, behavioral symptoms, and seizures. Additionally, ATP2B2 was investigated in the context of genetic hearing loss, and CRISPR-Cas9 ribonucleoprotein delivery was used to edit the gene and restore hearing function in mouse models. Finally, ATP2B2 was analyzed in head and neck squamous cell carcinomas, where low expression of the gene was associated with worse overall survival. These studies highlight the diverse applications of ATP2B2 in different fields of research.

    Protocols

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    FAQ

    chat Cameron Smith (Verified Customer)

    How does ATP2B2 affect auditory sensitivity? Oct 03 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Changes in cochlear ATP2B2 expression correlate with the maturation of auditory sensitivity, suggesting its involvement in the normal development of hearing. Oct 03 2020

    chat Casey Miller (Verified Customer)

    What is the impact of ATP2B2 mutations on hearing impairment? Dec 25 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Mutations in ATP2B2, a major calcium pump gene, cause deafness in mice, defining a new class of deafness genes that directly affect hair-cell physiology. Dec 25 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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