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    mProX™ Human ANO1 Stable Cell Line

    [CAT#: S01YF-1023-PY257]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;PC-3;RWPE-1
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Digestive and Renal Research
    Related Diseases
    Intestinal Dysmotility Syndrome; Gastric Leiomyoma
    Gene ID
    Human:55107
    UniProt ID
    Human:Q5XXA6

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The calcium-activated chloride channel ANO1 has been studied in various contexts. In one study, it was found that ANO1 may play a protective role in amyotrophic lateral sclerosis (ALS) by activating EGFR and CaMKII signaling. Another study focused on the role of ANO1 in lymphatic muscle cell pacemaking, specifically in the context of knock-out of Ano1 or IP3R. It was discovered that ANO1 is involved in the rhythmic action potentials and calcium ion concentration in lymphatic vessels. Additionally, ANO1 was investigated in colonic epithelium from cystic fibrosis patients and healthy individuals, where it was found to modulate CFTR activity but not function as an apical anion channel. Lastly, ANO1 was identified as a potential drug target in human pheochromocytoma and paraganglioma, with increased expression observed in these tumors. Overall, ANO1 has been implicated in various cellular processes and diseases, highlighting its potential as a therapeutic target.

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    There are currently no Customer reviews or questions for mProX™ Human ANO1 Stable Cell Line (S01YF-1023-PY257). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Casey Davis (Verified Customer)

    Does ANO1 overexpression affect cancer cell proliferation? Feb 20 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Overexpression of ANO1 in laryngocarcinoma Hep-2 cells does not significantly alter proliferation but increases migration, spreading, and detachment capacities, indicating its role in cancer cell motility. Feb 20 2021

    chat Morgan Miller (Verified Customer)

    How does ANO1 affect cardiac fibroblast differentiation? Feb 22 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ANO1 expression is closely related to the differentiation of myocardial fibroblasts and may be involved in modulating myocardial fibrosis. Feb 22 2023

    Related Products by Target
    • mProX™ Human ANO1 Stable Cell Line (CAT#: S01YF-1023-PY257)
    • Magic™ mPro Human ANO1 Cell Line (CAT#: S01YF-1122-KX129)
    • Magic™ Human ANO1 HEK293 Cell Line (CAT#: S01YF-0123-KX521)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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