mProX™ Human AKR1B1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Published Data
Fig.1 Knockdown or overexpression AKR1B10 in HCT116 cell lines.
A Western blot analysis successfully validated the effective suppression of AKR1B1 (using shB1 Clone 1 and shB1 Clone 2) and the introduction of exogenous AKR1B10 in HCT-116 cells. Statistical analysis revealed highly significant differences with ****p < 0.0001 and **p < 0.01, indicating the robustness of the observed outcomes.
Ref: Taskoparan, Betul, et al. "Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer." Cellular Oncology 40 (2017): 563-578.
Pubmed: 28929377
DOI: 10.1007/s13402-017-0351-7
Research Highlights
Diao, Hongting. et al. "Del Nido Cardioplegia or Potassium Induces Nrf2 and Protects Cardiomyocytes Against Oxidative Stress." American journal of physiology. Cell physiology, 2023.
Open heart surgery is a common treatment for coronary artery disease and is often necessary. However, the procedure can lead to reperfusion injury, which can impact cardiac performance and long-term outcomes. The authors examined whether the use of cardioplegia during cardiopulmonary bypass surgery activated Nrf2, a transcription factor that regulates antioxidant and detoxification genes. They found that commonly used cardioplegic solutions, such as High K+/Plegisol, led to activation of Nrf2 and resulted in significant improvements in postoperative cardiac function.
Diao, Hongting. et al. "Del Nido Cardioplegia or Potassium Induces Nrf2 and Protects Cardiomyocytes Against Oxidative Stress." American journal of physiology. Cell physiology, 2023.
Pubmed:
37842750
DOI:
10.1152/ajpcell.00436.2022
Feltrin, Isabella Rio, et al. "Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus." Theriogenology (2023).
In a study involving Nelore heifers, the impact of 17β-estradiol (E2) treatment on day 15 of the estrous cycle was investigated with regard to genes involved in the synthesis of prostaglandin F2α (PGF2α). The heifers underwent hormonal synchronization, and their corpus luteum (CL) area, blood perfusion, and progesterone (P4) plasma levels were monitored. On day 15, they were divided into a Control group and an Estradiol group. The Estradiol group exhibited significantly higher PGFM concentrations at 6 and 7 hours after treatment, indicating an accelerated luteolysis process. Notably, E2 treatment upregulated PGR and OXTR within 3 hours, providing novel insights into cattle luteolysis triggered by E2.
Feltrin, Isabella Rio, et al. "Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus." Theriogenology (2023).
Pubmed:
37783065
DOI:
10.1016/j.theriogenology.2023.09.019
