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    mProX™ Human AKR1B1 Stable Cell Line

    [CAT#: S01YF-1023-PY146]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HCT116
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Diabetic Neuropathy; Diabetic Cataract
    Gene ID
    Human:231
    UniProt ID
    Human:P15121

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    AKR1B1, also known as aldose reductase, has various applications in different fields. In the context of cardiac health, AKR1B1 is involved in protecting cardiomyocytes against oxidative stress during open heart surgery. It is activated by cardioplegic solutions, such as Del Nido, and induces the expression of antioxidant and detoxification genes. In bovine females, AKR1B1 is associated with the uterine luteolytic cascade, specifically in the synthesis of prostaglandin F2α. In breast cancer, AKR1B1 is regulated by the p53 tumor suppressor and is implicated in metastasis promotion. In gastric cancer, AKR1B1 is overexpressed and indicates poor prognosis. It regulates the AKT-mTOR pathway, contributing to cancer progression. Additionally, AKR1B1 is involved in the antifungal mechanism of Cinnamomum cassia essential oil against Candida albicans, and its functional components have been identified. Overall, AKR1B1 plays diverse roles in different biological processes and diseases.

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    FAQ

    chat Casey Brown (Verified Customer)

    Is AKR1B1 a significant biomarker in ovarian cancer? Feb 13 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, AKR1B1 is involved in the pathogenesis of high-grade serous ovarian cancer and can serve as a potential prognostic biomarker. Feb 13 2022

    chat Casey Miller (Verified Customer)

    How does AKR1B1 contribute to drug resistance in lung cancer? Mar 10 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    AKR1B1 enhances glutathione synthesis, leading to resistance to EGFR-targeted therapy in lung cancer, and its inhibition can restore drug sensitivity. Mar 10 2021

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    • Magic™ Human AKR1B1 NCI-H1975 Cell Line (CAT#: S01YF-0123-KX66)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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