GPCR Drug Discovery Services
As a pioneer and the undisputed global leader in membrane protein drug discovery, Creative Biolabs is proud to offer our clients a series of GPCR drug discovery services with the best quality and most competitive price. Here, we are happy to introduce our professional service of GPCR drug discovery with our diverse technologies.
G protein-coupled receptors (GPCRs) represent the largest and most important membrane protein family encoded by the human genome. Their endogenous ligands vary from photons, amines, carbohydrates, lipids, peptides to proteins. These receptors have been implicated in a large number of diseases, such as inflammatory disorders, cardiac disorders, and cancer, and serve as increasingly attractive drug targets. The GPCR family is divided into classes A (rhodopsin), classes B (secretin and adhesion), classes C (glutamate), and classes F (Frizzled) subfamilies.
Fig.1 Phylogenetic tree of GPCRs as drug targets. (Yang, et
al., 2021)
GPCR Cell-based Drug Screening In Vitro Assay Development Services
Creative Biolabs offers one-stop services from GPCR cell lines development to drug discovery in vitro assay.
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GPCR Antibody Discovery and Development Services
Creative Biolabs is specialized in GPCR antibody discovery with our reliable, fast methodologies and diverse technologies.
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GPCR Profiling Services with Various Panels
Creative Biolabs offers various panels include different GPCR targets to decrease wasted time on investigating suboptimal leads.
Learn MoreGPCR Cell-based Drug Screening In Vitro Assay Development Services
GPCR cell-based drug screening in vitro assay development services rely on changes in the intracellular concentration of secondary messengers upon ligand binding, such as cAMP, IP3, Ca2+, β-arrestin, etc. These changes result from the activation of one or more G proteins. From GPCR cell line development to drug discovery in vitro assay, Creative Biolabs is a one-stop shop for GPCR drug screening.
Fig.2 Diagrammatic representation of how G protein inhibition can bias GPCR signaling.
(Campbell & Smrcka, 2018)
GPCR Antibody Discovery and Development Services
As a pioneer and the undisputed global leader in antibody discovery, Creative Biolabs is specialized in membrane protein antibody discovery with our reliable, fast methodologies and diverse technologies. Our membrane protein antibody discovery process includes target selection and antigen preparation, assay development, hit generation, lead selection, lead optimization and characterization, candidate selection, and antibodies application.
Fig.3 Schematic representation of different antibody discovery strategies. (Laustsen, et
al., 2021)
GPCR Profiling Services with Various Panels
Creative Biolabs offers various panels including different GPCR targets to decrease wasted time on investigating suboptimal leads. Functional assays are used in Creative Biolabs' panels to circumvent the limits of binding assays for allosteric or non-functional binders, as well as to eliminate binding false positives.
Please contact us for more details about our GPCR drug discovery services. Our experts will help design an optimal solution for your project and troubleshoot for you throughout the whole process.
References
- Yang, D.; et al. G protein-coupled receptors: structure- and function-based drug discovery. Sig Transduct Target Ther. 2021; 6 (7).
- Campbell, AP.; Smrcka, AV. Targeting G protein-coupled receptor signaling by blocking G proteins. Nature Reviews Drug Discovery. 2018;17(11): 789.
- Laustsen, A.H.; et al. Animal immunization, in vitro display technologies, and machine learning for antibody discovery. Trends in Biotechnology. 2021; 39(12): 1263-1273.
