mProX™ Human ADGRE1 Stable Cell Line

Product Information

Target Protein

ADGRE1

Target Family

Orphan Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Orphan Receptor Research

Gene ID

2015

UniProt ID

Q14246

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

EMR1/ADGRE1 is an orphan receptor that is a member of the group II adhesion G protein-coupled receptors (aGPCRs) epidermal growth factor (EGF)-like module-containing mucin-like hormone receptor (like) subfamily with seven transmembranes. EMR1, also known as F4/80, is a recently developed marker for myeloid cells in humans, including eosinophils and macrophages. EMR1 is a well-established pan-macrophage marker in mice. It can operate as a regulator of immune cell function and is inducible during monocyte-macrophage development from progenitors in the bone marrow. EMR1 has been employed in numerous studies as a TAM marker and as a prognostic biomarker in various malignancies. The customized ADGRE1 stable cell line can be employed in the signaling pathway researches, as well as the screening of potential therapeutic candidates.

Protocols

Please visit our protocols page.

Customer Reviews

chat Burt

Excellent service! Very reliable. Fast turnaround time. And great communications. Oct 29 2022

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chat David

I recomended those Knock out cell line to my lab members. The delivery is much faster than I expected. Jan 22 2023

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FAQ

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Published Data

Fig.1 High EMR1 expression in colon cancer cells.

Western blot examination showed that after 48 h of CM treatment, relative EMR1 protein expression was found in both myeloid-derived HCT15 and Caco2 cancer cells.

Ref: Akter, Rokeya, et al. "EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer." Biomedicines 10.12 (2022): 3121.

Pubmed: 36551877

DOI: 10.3390/biomedicines10123121

Research Highlights

These three hub genes, ADGRE1, CCL18, and LILRA6, may have a role in the development of PCPG and could be used as novel treatment targets and potential biomarkers.
Chen, C. X., et al. Identification of vital prognostic genes related to tumor microenvironment in pheochromocytoma and paraganglioma based on weighted gene co-expression network analysis. Aging (Albany NY). 2021, 13(7), 9976.
Pubmed: 33795528 DOI: 10.18632/aging.202754

Worldwide, non-alcoholic steatohepatitis (NASH), which is directly related to obesity, is a health concern.
Kim, M. B., et al. Sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis. The Journal of Nutritional Biochemistry. 2021, 97, 108799.
Pubmed: 34119629 DOI: 10.1016/j.jnutbio.2021.108799

Multiple physiological processes, including the immune system, are impacted by malnutrition. The exact mechanism by which starvation lowers immune responses is still unknown.
Nakayama, K., et al. Activation of macrophages mediates dietary restriction-induced splenic involution. Life Sciences. 2022, 310, 121068.
Pubmed: 36243119 DOI: 10.1016/j.lfs.2022.121068