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  • Human CD19 Membrane Protein Mammalian Transient Expression Plasmid

    [CAT#: S01YF-1124-KX357]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein Plasmids

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    Certificate of Analysis Lookup
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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order plasmid encoding human CD19 for Protein Expression.
    Target Protein
    CD19
    Target Protein Species
    Human
    Target Classification
    CD
    Target Research Area
    Autoimmune Research; Immunology Research
    Related Diseases
    Immunodeficiency
    Target Family
    CD
    Vector
    pME
    Vector Type
    Mammalian Transient Expression Vector
    Note
    Resistance
    AmpR
    Growth Temperature
    37°C
    Relevant Promoters
    CMV, SV40, EF1a, CAG etc.
    Mutation
    Based on specific requirements
    Expressed Tags
    Based on specific requirements (Flag, StrepII, His, etc.)

    Product Properties

    Applications
    Protein Expression
    Shipping
    Blue Ice
    Storage
    Aliquot and store at -20°C for long term.

    Target

    Full Name
    CD19 molecule
    Introduction
    This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Alternative Names
    CD19; B4; CVID3; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12; differentiation antigen CD19; CD19 molecule
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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