GPCR Profiling Services with 32-targets Safety Panel

GPCRs are the class of pharmacological targets that have been investigated the most and have a track record of being useful targets. GPCRs are cell surface receptors that react to a range of extracellular stimuli and transmit responses, starting intracellular signaling pathways that result in a variety of physiological effects. This is why GPCRs are so significant pharmacologically.

Researchers can assess the specificity and selectivity of leads using GPCR panels, which enables them to identify any possible off-target effects that could have negative clinical consequences. For chemical profiling, secondary screening, and primary screening, assay panels are quite helpful. Creative Biolabs can provide GPCR profiling services with 32-targets safety panel to meet the needs of our clients in GPCR drugs development.

Receptor Families in Creative Biolabs' 32-targets Safety Panel

• Adenosine Receptors

Adenosine receptors modulate a number of disease processes in addition to playing significant roles in controlling normal cell function. The release of neurotransmitters, synaptic plasticity, and neuroprotection after ischemia insult, hypoxia, and oxidative stressors are all mediated via receptors in the central nervous system.

• Adrenergic Receptors

Nearly every peripheral tissue as well as numerous neuronal populations in the sympathetic and central nervous systems include beta-adrenergic receptors. When the endogenous catecholamines noradrenaline and adrenaline bind to them, they initiate intracellular signaling cascades.

• Angiotensin Receptors

Numerous tissues have high expression levels of angiotensin receptors. They are in charge of the primary effector hormone's signal transduction.

• Cannabinoid Receptors

The GPCR family of receptor proteins that are most frequently expressed in the brain are cannabinoid receptors. Their involvement spans across different facets of central nervous system activity and diseases.

• Cholecystokinin Receptors

Cholecystokinin receptors, which are significant neurointestinal peptide hormone receptors, are crucial for regulating appetite and food intake.

• Dopamine Receptors

Dopamine receptors are found throughout the brain, where they have a major impact on motivation, drive, and motor activities in addition to cognition.

• Histamine Receptors

A major and critical role for histamine receptors is played in the development of many allergy disorders. Histamine receptors (H1R–H4R) are classified according to their distribution, function, structure, and affinity for histamine.

• Endothelin Receptors

Endothelins are ubiquitous vasoactive peptides generated by endothelium that play a physiological role in maintaining vascular tone. This is consistent with the widespread expression of endothelin receptors in all tissues.

• Muscarinic Receptors

The human body contains full of muscarinic receptors, each of which mediates a different physiological function depending on its location and receptor subtype (M1–M5).

• Opioid Receptors

Opioid receptors mediate the actions of opioids, which are important for the clinical management of pain and drug addiction. Opioid receptors are among the earliest receptor systems identified in the central nervous system.

• Serotonin Receptors

Almost all animals have serotonin receptors in their peripheral and central nervous systems. Serotonin receptors cause a serotoninergic reaction by initiating an intracellular second messenger cascade.

• Vasopressin Receptors

Arginine vasopressin, is a nonpeptide hormone that is produced in the hypothalamic paraventricular and supraoptic nuclei. There are three different subtypes of vasopressin receptors: V1, V2, and V3.

Targets of Creative Biolabs' 32-targets Safety Panel