Vasopressin GPCR Assays

Background of Vasopressin Receptors

Vasopressin receptors belong to the family of G protein-coupled receptors (GPCR). The Vasopressin receptors mediate various biological functions, such as vasoconstriction, antidiuresis, and adrenocorticotropic hormone (ACTH) release.

Fig.1. Physiological effects of vasopressin. (Demiselle, 2020)

Distributions and Functions of Vasopressin Receptors

AVPR1A is found in high density on vascular smooth muscle and induces various biological functions, such as vasoconstriction, facilitating thrombosis, and stimulating VEGF secretion. AVPR1B located in the hypothalamus controls ACTH secretion, while AVPR1B located in the pancreas is involved in insulin release. The expression of AVPR2V2 can only be found on the basolateral membrane of collecting duct cells in the kidney, for the regulation of water excretion.

Subtypes and Mechanisms of Vasopressin Receptors

There are three subtypes of vasopressin receptors, including arginine vasopressin receptor 1A (AVPR1A), Arginine vasopressin receptor 1B (AVPR1B), and Arginine vasopressin receptor 2 (AVPR2).

Assay List of Vasopressin Receptors

Creative Biolabs can provide a range of assays of vasopressin receptors. You can choose the assay in the list or contact us for more information:

Published Data

References

1. Demiselle, J.; et al. Vasopressin and its analogues in shock states: a review. Annals of intensive care. 2020, 10(1): 1-7.
2. Natochin, Y.V.; Golosova, D.V. Vasopressin receptor subtypes and renal sodium transport. Vitamins and Hormones. 2020, 113: 239-258.