Two P Domain Potassium Channel Related Drug Discovery Products
Almost all types of cells include potassium channels in their plasma membranes, which play a crucial role in regulating cellular processes like excitability, volume, growth and proliferation, and even cell death. Two, four, or six transmembrane (TM) segments and one or two poreforming (P) domains are present in each K+ channel subunit. It is now known that some background (or leak) K+ channels present in a variety of cells belong to this type, which contains four transmembrane segments and two pore-forming domains (K2P channel family). The channel members are believed to be dimers since each K2P channel subunit has two pore-forming regions. Creative Biolabs can offer two P domain potassium channel related products to contribute to the success of drug discovery.
Overview of Two P Domain Potassium Channel
Tandem-pore Acid-Sensing K+ channel subtypes TASK-1 and TASK-3 are two members of the K2P channel family. The human TASK-1 is 395 amino acid polypeptide expressed in numerous tissues, although the brain, placenta, and pancreas are where it is most prevalent. The granular layer of the cerebellum and somatic motor neurons are two areas of the brain where TASK-1 mRNA is expressed. Human TASK-3 is a 374 amino acid polypeptide that has 62% similarity to TASK-1. The carboxy-terminus of TASK-1 and TASK-3 differ significantly from one another. The central nervous system, specifically the cerebellum, expresses human TASK-3 mRNA to a greater extent than other regions. Both TASK-1 and TASK-3 have background K+ channel characteristics, such as being active over the physiological range of membrane potentials, activating and deactivating quickly in response to voltage changes, and exhibiting little to no inactivation. In the expression systems, TASK-3 current tends to be significantly greater than TASK-1 current for unknown reasons, maybe because of elements that control cell surface expression.
The TREK family has a member known as TREK-1 (TWIK-Related K+ channel-1). Human TREK-1 is a 411 amino acid polypetide, and different parts of the brain as well as the smooth muscle cells of the stomach and intestine express its mRNA. TREK-2 and TREK-1 are closely related, with 65% of their amino acids being the same. The fundamental distinction between TREK-1 and TREK-2, like with other members of the TASK family, is found in the amino acid sequence at the carboxy terminus. The 538 amino acid polypeptide known as human TREK-2 is expressed in different parts of the brain via its mRNA. TREK-2 mRNA is mostly expressed in the granular cell layer of the cerebellum. The pancreas and kidney are examples of peripheral organs that express TREK-2 mRNA.
