Lipid Nanoparticles for Nucleic Acids Delivery

Introduction

Nucleic acids have demonstrated significant potential as research tools for investigating gene function and biological mechanisms. However, their intracellular delivery often presents a formidable challenge. Lipid nanoparticles (LNPs) have gained traction as a versatile delivery system for nucleic acids, including mRNA, siRNA, and DNA, in research applications. The successful application of LNP-formulated mRNA COVID-19 vaccines has further spurred interest in this technology. Creative Biolabs specializes in providing off-the-shelf and custom LNP solutions to facilitate nucleic acid delivery for research purposes.

Fig.1 LNP-encapsulated mRNAs (Creative Biolabs AI, 1-6-3-Lipid-Nanoparticles-for-Intracellular-Delivery-1)

Creative Biolabs Provides off-shelf LNPs for Nucleic Acid Delivery

Creative Biolabs offers a range of preformulated LNPs optimized for encapsulating and delivering various types of nucleic acids for research applications. Our off-the-shelf LNP formulations incorporate ionizable lipid components that have been carefully designed and selected for robust encapsulation and intracellular release of the nucleic acid cargo. These LNPs are produced using microfluidic mixing technology under well-defined conditions to achieve consistent nanoparticle characteristics. Stringent quality control assays are conducted on each batch of LNPs to ensure they meet research-grade specifications. Creative Biolabs' off-the-shelf LNPs provide a ready-to-use tool for investigating nucleic acid delivery in research settings.

Creative Biolabs Offers Custom LNPs for Nucleic Acid Delivery Research

Creative Biolabs also provides custom LNP development services to support client's specific research needs. Leveraging our exclusive library of novel ionizable lipids and extensive formulation expertise, we can design and optimize LNPs with tailored composition and properties for delivering different nucleic acid cargoes to target cell types of interest. Our advanced microfluidic platform allows efficient, high-throughput production and screening of LNP formulations to identify the most promising candidates. We also provide comprehensive analytical testing to characterize the LNPs' physicochemical attributes and ensure their research-grade quality.

Applications of Protein Delivery with LNPs

Investigate gene function and regulation by delivering mRNA or siRNA to modulate target expression
Elucidate disease mechanisms and discover novel therapeutic targets using LNP-mediated RNAi or CRISPR screening
Evaluate genome editing efficiency and specificity of CRISPR-Cas9 formulated in LNPs in preclinical models
Assess the pharmacokinetics, biodistribution, and pharmacology of antisense oligonucleotides or aptamers encapsulated in LNPs
Develop and optimize novel gene delivery systems for ex vivo cell engineering or in vivo gene therapy research

Advantages of Drug Delivery with Inorganic Nanoparticles

Efficient packaging of anionic nucleic acids via charge interaction with ionizable lipids
Versatility to encapsulate diverse nucleic acid cargoes, including mRNA, siRNA, and DNA
Potent intracellular delivery enabled by endosomal escape
Biodegradability and biocompatibility with research-relevant cell types
Scalable and reproducible manufacture for research use

Target Search

Note: All of our products are for Research Use Only (RUO). NOT intended for diagnostic, therapeutic or clinical use. We DO NOT offer patients any direct products or services. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.