TGFB1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
| Full Name | Transforming growth factor beta 1 |
| Gene ID | Human: 7040 Mouse: 21803 Rat: 59086 Monkey: 106992315 |
| UniProt ID | Human: P01137 Mouse: P04202 Rat: P17246 Monkey: P09533 |
| Alternative Names | CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1; transforming growth factor beta-1 proprotein; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1; transforming growth factor beta1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TGFB1 Target Family: Oncology Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
