Target-Relevant Cancer Cell Line Screening Service

In vitro research uses cell lines to generate meaningful models that represent human biology in both health and illness at an early stage of drug discovery and development. Creative Biolabs offers target-relevant cancer cell lines screening service. With our extensive offerings, selecting the appropriate cell lines for your novel agents' in vitro assessment is quick and simple.

High-throughput screening (HTS) is a widely used method in drug development that involves assessing the toxicity or sensitivity of hundreds of pharmacological molecules on panels of cell lines in order to identify a small number of hit compounds that have the appropriate response patterns for further investigation. Unlike target-based drug discovery, which starts with a single, disease-related protein, phenotype-based drug discovery procedures profile the complex biological system as a whole in an attempt to uncover small molecules or other bioactive compounds causing specific cellular phenotypes. Target-relevant cell lines are necessary to map the observed cellular responses of pharmaceuticals to the underlying drug-target interaction networks and evaluate the cell context-specific mechanisms of the drugs' action.

Fig.1. Schematic overview of screening service. ¹

Feature of Target-Relevant Cancer Cell Lines Screening Service

In order to improve patient outcomes, the true challenge in cancer research is to have a thorough understanding of the mechanisms and causation behind the behaviors of cancer cells. A better understanding of the mechanisms behind cell survival under stress is made possible by the longitudinal data, which offer significantly more information on both the baseline biological network wiring and the alterations that are connected with it under stress. Using an effective, reliable RNA measuring platform, a connectivity map of the analyzed mRNA responses of cancer cell lines to various perturbations has been created. These investigations offer important tools for learning about cancer mechanisms and manifestations at the systems level. To help you choose from our target-relevant cancer cell lines screening service, Creative Biolabs offers a commercial database of well-characterized cell lines along with RNAseq data and standard of care.

Applications of Target-Relevant Cancer Cell Lines Screening Service

In order to find biomarkers that predict drug response, thousands of cancer cell lines have been evaluated for sensitivity to hundreds of anti-cancer medications using matched multi-omic data. The issue of matching patients to medications remains unresolved despite significant efforts in this direction. Also, a lot of chemotherapy regimens include combinations of three or four medications. Clinically, it is not practical to conduct a thorough experimental investigation of merely two-way pharmacological combinations for hundreds of anti-cancer medications over a representative cohort. Our target-relevant cancer cell lines screening service at Creative Biolabs can carry out more intricate combination studies or simpler single agent assays to find additive or synergistic effects.

Our cell lines are regularly used for research projects. They are all STR confirmed and mycoplasma tested. Please contact us for more information.

Reference

1. Wang T, Gautam P, Rousu J, Aittokallio T. Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer. Comput Struct Biotechnol J. 2020;18: 3819-3832.