ADGRL1
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
| Full Name | Adhesion G protein-coupled receptor L1 |
| Gene ID | Human: 22859 Mouse: 330814 Rat: 65096 Monkey: 718708 |
| UniProt ID | Human: O94910 Mouse: Q80TR1 Rat: O88917 Monkey: F7C0U1 |
| Alternative Names | CL1; LEC2; CIRL1; LPHN1; CIRL-1; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1; lectomedin-2; ADGRL1; Adhesion G protein-coupled receptor L1 |
Product List
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mProX™ Human ADGRL1 Stable Cell Line
[CAT#: S01YF-0223-KX28]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ADGRL1 Target Family: Orphan Family Target Protein Species: Human Host Cell Type: NB2a; CHO-K1; HEK293
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