jRCaMP1 Sensor Tools
- Product Category:
- Membrane Staining and Imaging Reagents
- Subcategory:
- Genetically Encoded Sensors
To image brain activity in vivo, scientists have created high-sensitivity red GECIs based on RCaMP. New RCaMP (jRCaMP1) variations based on mRuby offer better sensitivity and kinetics. There are two jRCaMP1 variants: jRCaMP1a and jRCaMP1b. In comparison to their parent sensors, jRCaMP1a and jRCaMP1b were also significantly enhanced. Compared to jRCaMP1b, jRCaMP1a has a higher sensitivity and slower degradation kinetics. The dynamic range of jRCaMP1b is greater and is unaffected by saturation in the range of 1-160 action potentials (APs). However, in cultured neurons and solution, jRCaMP1a has a highly constrained dynamic range. In the calcium-bound form, jRCaMP1a and jRCaMP1b are two times brighter than jRGECO1a. Both reagents have had their performance assessed in cultured neurons as well as in vivo in mice, Drosophila, zebrafish, and C. elegans. Creative Biolabs has developed several jRCaMP1-related tools to boost our global customers' research and project goals.
- Plasmid
- Cell line
- Virus
