GRAB_HA Sensor Tools

Histamine (HA), a crucial biogenic monoamine, is involved in numerous physiological and pathological processes in the central and peripheral nervous systems. Numerous G-protein-coupled receptor-activation-based (GRAB) HA (GRAB_HA) sensors with good photostability, sub-second kinetics, nanomolar affinity, and high selectivity have been developed by researchers. These GRAB_HA sensors were used to acquire extremely precise spatiotemporal measurements of electrical stimulation-evoked HA release in acute brain slices. Additionally, by analyzing HA release in the preoptic area of the hypothalamus and the prefrontal cortex throughout the sleep-wake cycle in freely moving mice, they were able to observe various patterns of HA dynamics between these specific brain regions. GRAB_HA sensors are trustworthy instruments for monitoring extracellular HA transfer in both healthy and diseased processes. Creative Biolabs offers GRAB_HA plasmids, viruses, and cell lines. Our highly qualified scientists are confident in their ability to offer the greatest products and services at the most affordable prices to both domestic and foreign clients.