GRAB_DA Sensor Tools
- Product Category:
- Membrane Staining and Imaging Reagents
- Subcategory:
- Genetically Encoded Sensors
A major monoamine neurotransmitter called dopamine (DA) is engaged in a wide range of physiological and pathological functions. The GPCR-Activation-Based-DA (GRAB_DA) sensors with genetic encoding were created. They make it possible to precisely and quickly detect endogenous DA dynamics in a variety of model systems, both in vivo and ex vivo. GRAB_DA sensors detect stimulus-evoked DA release in the mesolimbic pathway in fresh mouse brain slices. When applied to flies, GRAB_DA sensors resolved DA release elicited by a single electrical stimulation as well as odor-driven DA release in the MB. GRAB_DA sensors detected chemogenetically triggered DA release in the optic tectum of transgenic zebrafish. Optogenetic stimulation and GRAB_DA sensors combined with mice allowed for simultaneous optical manipulation and in vivo monitoring of DA signals. Creative Biolabs can provide GRAB_DA plasmids, viruses and cell lines, and custom GRAB_DA-related tools.
- Plasmid
- Cell line
- Virus
