GluSnFR Sensor Tools
- Product Category:
- Membrane Staining and Imaging Reagents
- Subcategory:
- Genetically Encoded Sensors
Fluorescence microscopy is utilized to observe the activity of presynaptic terminals using glutamate-sensitive fluorescent reporters (iGluSnFR). A class of optogenetic sensors called GluSnFRs is employed in neuroscience studies. Two-photon microscopy is frequently used to track GluSnFR fluorescence in brain tissue. The commonly used iGluSnFR is made up of a bacterial glutamate binding protein (GluBP) linked to a circularly permuted enhanced green fluorescent protein (cpEGFP). The structure of GluBP is altered when it binds a glutamate molecule, drawing the EGFP barrel together and boosting fluorescence. To move the sensor outside of the cell membrane, a certain peptide fragment (PDGFR) is added. Creative Biolabs is a recognized service provider in genetically encoded sensors. We can offer GluSnFR plasmids, viruses, and cell lines for our clients.
- Plasmid
- Cell line
- Virus
