Clomeleon Sensor Tools
- Product Category:
- Membrane Staining and Imaging Reagents
- Subcategory:
- Genetically Encoded Sensors
A genetically encoded indicator called clomeleon allows for the optical assessment of resting Cl- in the physiologically appropriate range and the observation of Cl- transients induced by the activation of GABA receptors. Contrary to organic Cl- dyes, Clomeleon expression can be directed at particular neuronal populations. Due to these characteristics, Clomeleon is well suited for research on a variety of little-studied aspects of Cl- regulation, such as activity-dependent ionic plasticity, compartmental gradients of Cl-, sensory signal transduction, and pathophysiological mechanisms in a wide range of disorders. It is made up of a flexible peptide linker connecting a CFP derivative to the Topaz yellow fluorescent protein. Cl- levels can be monitored using fluorescence resonance energy transfer (FRET), which involves the interaction of Topaz and the CFP derivative. Creative Biolabs has successfully developed Clomeleon plasmids, viruses, and cell lines to meet your needs.
- Plasmid
- Cell line
- Virus
| Product Name | Cat# | Serotype | Reporter Gene | Titer Unit | Size | Datasheet | Inquiry |
|---|---|---|---|---|---|---|---|
| Custom Clomeleon Lentiviral Virus | S01YF-0623-KX70 | N/A | >10⁸ TU/mL | ||||
| Custom Clomeleon AAV Virus | S01YF-0623-KX71 | >10¹² v.g./mL |
