mProX™ Human IL2RB Stable Cell Line

Product Information

Target Family

Immune Checkpoint

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;BEAS-2B

Target Classification

Immune Checkpoint Cell Lines

Target Research Area

Immunology Research

Related Diseases

Immunodeficiency 63 With Lymphoproliferation And Autoimmunity; Ichthyosis

Gene ID

Human:3560

UniProt ID

Human:P14784

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL2RB, which encodes the interleukin 2 receptor subunit beta, has been found to be associated with various health conditions and diseases. In adult subjects with asthma, SNPs in the IL2RB gene region have been linked to fractional exhaled nitric oxide (FeNO), a biomarker for airway inflammation. IL2RB is involved in immune response processes and contributes to the understanding of FeNO in asthma. In pediatric hypertension, IL2RB is one of the genes that exhibit enhanced expression in association with elevated blood pressure. It is part of the proinflammatory and cytotoxic immune profile observed in hypertensive individuals. In endometriosis, IL2RB is one of the genes found to carry rare and damaging variants in patients. These variants contribute to the genetic architecture of the disease and provide insights into genotype-phenotype correlations. In the liver of domesticated Tinca tinca (tench), IL2RB is among the genes that are upregulated in response to successive domestication. It is involved in immune response and contributes to the physiological modifications related to protein processing, immune response, and hormone metabolism in domesticated tench. In a zebrafish model of Parkinson's disease, rotenone exposure leads to dysregulation of dopamine-related gene expression, including IL2RB. IL2RB is upregulated along with genes involved in cytotoxic T lymphocytes, T cell receptor signaling, microgliosis regulation, cellular response to IL-1, and regulation of apoptotic process. These findings suggest that IL2RB plays a role in the pathogenesis of Parkinson's disease.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Jones (Verified Customer)

How does IL2RB affect immune cell function? Jul 25 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

IL2RB is involved in immune cell differentiation and function, influencing the balance of Th1/Th2 responses and playing a role in immune disorders. Jul 25 2020

chat Skyler Davis (Verified Customer)

What is the impact of IL2RB in sepsis-induced immune dysfunction? Jul 28 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

IL2RB expression can improve sepsis-induced immunological dysfunction and balance Th1/Th2 responses, indicating its therapeutic potential in sepsis management. Jul 28 2022

Published Data

Fig.1 The significance of LPS-induced apoptosis and inflammatory cytokine production in BEAS-2B cells was underscored by the indispensability of miR-497-5p/IL2RB.

BEAS-2B cells were subjected to stimulation by LPS, and subsequent treatment involved the administration of a miR-497-5p inhibitor along with si-IL2RB. The expression of IL2RB was detected through Western blotting. Additionally, cell viability was assessed using the MTT assay.

Ref: Lou, Wei, Jieping Yan, and Weisi Wang. "Downregulation of miR-497-5p improves sepsis-induced acute lung injury by targeting IL2RB." BioMed Research International 2021 (2021).

Pubmed: 33954185

DOI: 10.1155/2021/6624702

Research Highlights

Accordini, Simone. et al. "SNPs in FAM13A and IL2RB genes are associated with FeNO in adult subjects with asthma." Journal of breath research, 2023.
Nitric oxide plays diverse roles in asthma, serving as both an inherent regulator of airway function and an instigator of inflammation. Fractional exhaled nitric oxide (FeNO) stands as a dependable, quantitative, non-intrusive, uncomplicated, and secure biomarker for appraising airway inflammation in asthma. An investigation was conducted, comprising 264 asthma cases, discovered among the general adult population in Verona, Italy, between 2008 and 2010. This study targeted the identification of single nucleotide polymorphisms (SNPs) within candidate genes or gene regions associated with FeNO in asthma. Machine learning via the gradient boosting machine (GBM) technique identified 15 significant SNPs, among which SNP rs987314 within the family with sequence similarity 13 member A (FAM13A) and SNP rs3218258 within the interleukin 2 receptor subunit beta (IL2RB) gene regions displayed notable associations with FeNO in adult asthmatic subjects. These genes exert influence on various mechanisms affecting smooth muscle constriction, endothelial barrier function responses (FAM13A), and immune response processes (IL2RB), expanding the understanding of FeNO's role in asthma.
Accordini, Simone. et al. "SNPs in FAM13A and IL2RB genes are associated with FeNO in adult subjects with asthma." Journal of breath research, 2023.
Pubmed: 37733009 DOI: 10.1088/1752-7163/acfbf1

Thürmann, Loreen, et al. "Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators." Hypertension (2023).
The role of inflammatory processes in causing vascular damage in pediatric hypertension has been proposed. The objective of this study was to examine changes in the activity of immune modulators and explore their correlation with office blood pressure in adolescents without a known diagnosis of hypertension during the study visit.
Thürmann, Loreen, et al. "Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators." Hypertension (2023).
Pubmed: 37675573 DOI: 10.1161/HYPERTENSIONAHA.123.21489