mProX™ Human IL2RB Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL2RB, which encodes the interleukin 2 receptor subunit beta, has been found to be associated with various health conditions and diseases. In adult subjects with asthma, SNPs in the IL2RB gene region have been linked to fractional exhaled nitric oxide (FeNO), a biomarker for airway inflammation. IL2RB is involved in immune response processes and contributes to the understanding of FeNO in asthma. In pediatric hypertension, IL2RB is one of the genes that exhibit enhanced expression in association with elevated blood pressure. It is part of the proinflammatory and cytotoxic immune profile observed in hypertensive individuals. In endometriosis, IL2RB is one of the genes found to carry rare and damaging variants in patients. These variants contribute to the genetic architecture of the disease and provide insights into genotype-phenotype correlations. In the liver of domesticated Tinca tinca (tench), IL2RB is among the genes that are upregulated in response to successive domestication. It is involved in immune response and contributes to the physiological modifications related to protein processing, immune response, and hormone metabolism in domesticated tench. In a zebrafish model of Parkinson's disease, rotenone exposure leads to dysregulation of dopamine-related gene expression, including IL2RB. IL2RB is upregulated along with genes involved in cytotoxic T lymphocytes, T cell receptor signaling, microgliosis regulation, cellular response to IL-1, and regulation of apoptotic process. These findings suggest that IL2RB plays a role in the pathogenesis of Parkinson's disease.