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  • mProX™ Human ETV6 Stable Cell Line

    [CAT#: S01YF-1023-PY141]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;LNCap;22RV1
    Target Classification
    Kinase Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Thrombocytopenia 5; Hematologic Cancer
    Gene ID
    Human:2120
    UniProt ID
    Human:P41212

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The applications of ETV6 include its role in the pathophysiology and prognosis of secondary hemochromatosis, its association with adverse risk markers in acute myeloid leukemia (AML), its involvement in the detection of Philadelphia chromosome-like B-acute lymphoblastic leukemia (B-ALL), and its identification in secretory carcinoma of salivary glands. ETV6 gene mutations and rearrangements are important in understanding the clinical course, diagnosis, and selection of optimal therapy for these conditions.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Morgan Jones (Verified Customer)

    What role does ETV6 play in monocyte differentiation? May 14 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ETV6, along with ETV3, enables monocyte differentiation into dendritic cells by repressing macrophage fate commitment. May 14 2023

    chat Alex Garcia (Verified Customer)

    How does ETV6 interact with the RUNX1 gene in leukemia? Dec 19 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ETV6-RUNX1 fusion is a well-established leukemia-initiating event, particularly in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Dec 19 2021
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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