Cyro-Scanning Electron Microscopy (Cryo-SEM) Imaging Service

Cryo-Scanning Electron Microscopy (Cryo-SEM) is an advanced imaging technique that combines the high-resolution capabilities of scanning electron microscopy with the ability to observe samples in their natural, hydrated state. By rapidly freezing samples, Cryo-SEM provides a unique window into the microscopic world, capturing intricate details that might be lost using traditional SEM techniques.

Fig.1 Representative cryo-SEM images of pulmonary mucus¹.

Cryo-SEM Applications

Advancements in Chemical Product Innovation

The acquisition of state-of-the-art Cryo-SEM instruments, such as the Gemini 500, has propelled research across various scientific domains. These instruments are not just limited to biological samples but extend their utility to geological specimens, fossils, soft materials, polymers, nanoparticles, electronics, and even the microstructures of building materials.

Diverse Sample Analysis

The versatility of Cryo-SEM is evident in its ability to analyze a wide range of samples. From biological tissues, geological specimens, and fossils to soft materials, polymers, nanoparticles, and microstructures of building materials, the applications are vast. This breadth of application ensures that researchers and industries can gain insights into almost any sample type, driving innovation and understanding.

Sample Requirements

We accept:

Fixed cell/tissue samples
Freshly collected samples.

Please include a detailed order form and sample submission form with your submission.

If you need to send fresh, unfixed samples, please contact us in advance to confirm the shipping method.

Service Turnaround Time

The service turnaround time is typically about 2 weeks after sample receipt. In the event of public holidays, the period may need to be extended. Please confirm the specific experiment cycle and sample submission time with Creative Biolabs.

Deliverables

For each sample, we provide 8 images (analysis service is not provided). If more images are required, additional charges will apply.

Please provide feedback on the results within one week of test completion. We do not recommend sample recovery. If needed, please inform Creative Biolabs in advance.

Creative Biolabs' Cryo-SEM Services

Creative Biolabs has been at the forefront of using Cryo-SEM technology. The organization has successfully applied this technology to study dynamic conformational changes and functions of macromolecular complexes. With extensive experience in characterizing structures of gene therapy and drug delivery particles, Creative Biolabs ensures top-notch Cryo-SEM services tailored to individual project needs.

For more information, please contact us.

FAQs

Q1: What sets Cryo-SEM apart from traditional SEM?

A: Cryo-SEM allows for the observation of samples in their natural, hydrated state, capturing details that might be altered or lost in traditional SEM.

Q2: What are the main applications of Cryo-SEM?

A: Cryo-SEM is versatile, finding applications in studying biological tissues, geological specimens, polymers, nanoparticles, and even building materials.

Q3: How does Creative Biology Lab ensure the best results in Cryo-SEM imaging?

A: With state-of-the-art equipment, a team of seasoned experts, and a rich history of successful projects, Creative Biology Lab provides unparalleled Cryo-SEM services tailored to individual project needs.

Reference

Barthold, Sarah, et al. "Overview of inhaled nanopharmaceuticals." Journal of Aerosol Medicine and Pulmonary Drug Delivery 36.3 (2023): 144-151.

Note: All of our products are for Research Use Only (RUO). NOT intended for diagnostic, therapeutic or clinical use. We DO NOT offer patients any direct products or services. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.