Cancer Cell Panel Screening Service

Creative Biolabs offers cancer cell panel screening services that provide rapid, cost-effective, and comprehensive cancer cell line screening. The panels are crucial to the screening process and are able to predict activity patterns. By integrating the panel screen with other techniques, we have been able to effectively assess test compounds across a variety of pharmacological domains.

The advancement of cancer chemotherapy depends on the creation of new, more potent drugs. Target molecule inhibitors have been the focus of recent advances in medication development. It has been demonstrated that they are causally related to cancer malignancy. Many protein kinase inhibitors are being developed, some of which have emerged as novel chemotherapeutic drugs. Apart from established targets, novel targets associated with apoptosis, angiogenesis, invasion, and cell cycle are being studied.

Advantages of Cancer Cell Panel Screening Service

• Screen sensitive cancer cell lines
• Determine appropriate indications
• Select the most susceptible cancer cell lines for use in CDX or cell models.
• Analyze genetic markers to forecast the effectiveness of anticancer drugs

Workflow of Cancer Cell Panel Screening Service

• Human cancer cell lines were seeded into 384-well microplates. After being incubated for the entire night, the cells were treated with compounds and then re-incubated for the experiment at a later time.
• ATP is measured using CellTiter-Glo. It is commonly acknowledged that ATP is a reliable indicator of living cells. The ability of cells to manufacture ATP is lost when their membranes break, and endogenous ATPases quickly use up whatever ATP that is still in the cytoplasm. The ATP detection reagent is made up of luciferin as a substrate, detergent to lyse the cells, ATPase inhibitors to stabilize the ATP released from the lysed cells, and stable form of luciferase to catalyze the reaction that produces light photons.
• The studied datasets integrate high throughput drug sensitivity screening with molecular characterization of cancer cell lines. Cell viability at various escalating drug doses was assessed for each drug-cell pair examined in a dataset, and the results were compared to an untreated control to determine the percentage of viability. It is desirable to obtain a single number summarizing the sensitivity of a certain cell line to a drug treatment in order to learn drug response predictors.

Cancer Cell Panel in Creative Biolabs

• 170 cancer cell lines panel

Creative Biolabs established and is investigating the potential of a panel of 170 human cancer cell lines covering 21 cancer types. Our panel has proved to be a powerful tool in drug evaluation and drug discovery.

• Customized cancer cell lines panel

Creative Biolabs has 500+ human cancer cell lines for cancer cell panel screening service. The cancer cell lines contain 30+ cancer types covering most cancer types, such as lung cancer, lymphoma, gastric cancer, breast cancer, prostate cancer, colon cancer, etc. Please contact us for more information.