mProX™ Human STK24 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Silencing STK24 in mouse M12 cells had no effect on cell proliferation rates.
The impact of STK24 silencing on cell proliferation rates was assessed in mouse M12 cells, and no significant effect was observed. Proliferation rates were evaluated at 24, 48, and 72 h for both M12 cells and STK24 sgRNA stable transfectants.
Ref: Hsu, Hui-Ping, et al. "Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model." Journal of Cancer 11.1 (2020): 213.
Pubmed: 31892988
DOI: 10.7150/jca.35821
Research Highlights
Caputo, Mara. et al. "STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies." FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023.
Hepatocellular carcinoma (HCC) is a highly lethal and rapidly growing cancer. Recently, nonalcoholic steatohepatitis (NASH), a condition characterized by liver inflammation, injury, and fibrosis, has become a significant contributor to HCC. The study aimed to investigate the role of STE20-type kinases MST3 and MST4 in NASH and their potential relevance in human HCC. Through analysis of public databases and in-house cohorts, it was found that the expression of MST3 and MST4 in the liver was positively correlated with the incidence and severity of HCC. Further research showed that silencing of both kinases suppressed the growth and invasiveness of human HCC cells, and this was attributed to decreased activation of STAT3 signaling and altered interactions with GOLGA2 and STRIPAK complexes. These findings suggest that MST3 and MST4 play a crucial role in the progression of HCC and targeting them may be a promising therapeutic approach for liver cancer.
Caputo, Mara. et al. "STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies." FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023.
Pubmed:
37490000
DOI:
10.1096/fj.202300397RR
Qiu, Jing. et al. "Molecular mechanisms involved in regulating protein activity and biological function of MST3." Cell division, 2023.
The mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-protein kinase 24 (STK24) is a vital serine/threonine protein kinase in the mammalian STE20-like protein kinase family. MST3 has a wide range of functions and plays a crucial role in regulating events such as apoptosis, immune response, metabolism, hypertension, tumor progression, and development of the central nervous system. The mechanisms of MST3 regulation, including protein activity, post-translational modification, and subcellular location, are complex and closely connected to its pleiotropic function. This review explores recent advancements in understanding the regulatory processes of MST3 and its contribution to disease progression.
Qiu, Jing. et al. "Molecular mechanisms involved in regulating protein activity and biological function of MST3." Cell division, 2023.
Pubmed:
37202821
DOI:
10.1186/s13008-023-00090-x
