mProX™ Human RXRB Stable Cell Line

Product Information

Target Protein

RXRB

Target Family

Retinoid X Receptor

Target Protein Species

Human

Host Cell Type

RCS; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Cardiovascular Research; Inflammation Research

Related Diseases

Granulomatosis With Polyangiitis; Vasculitis

Gene ID

6257

UniProt ID

P28702

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The RXRB gene in humans codes for the nuclear receptor known as retinoid X receptor beta (RXR-beta). One of the nuclear receptors of the retinoid X receptor (RXR) family, which mediates the actions of retinoic acid (RA), is encoded by this gene. Together with the thyroid hormone, vitamin D, and retinoic acid receptors, this receptor produces heterodimers that enhance transcriptional activity on the corresponding response element as well as DNA binding. The gene is located on chromosome 6 in the major histocompatibility complex (MHC) class II region. Although a transcript variation with alternative splicing has been identified, its entire sequence remains unknown. The customized RXRB stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Cynthia

This RXRB overexpression cell line has saved us time and resources. Our team is excited to delve deeper into our investigations. Jan 02 2022

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chat Barbara

I think this mouse RXRB KD cell line is better than many similar products already on the market. Nov 20 2022

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FAQ

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Published Data

Fig.1 Different expression patterns of the Rxrb and Col11a2 genes.

Northern blots with 10 g of total RNA per lane from each tissue of mouse embryos that were 16.5 days postcoitus, along with each cell line (shown at the top of the panels) that hybridized to Rxrb and Col11a2 probes.

Ref: Murai, Junko, et al. "Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2." Journal of Biological Chemistry 283.41 (2008): 27677-27687.

Pubmed: 18682388

DOI: 10.1074/jbc.M803657200

Research Highlights

RXRB's role as a primary effector of RAB39A was confirmed when induced overexpression of the protein restored spherogenic capacity and tumorigenesis in RAB39A-silenced cells.
Chano, Tokuhiro, et al. "Prominent role of RAB39A-RXRB axis in cancer development and stemness." Oncotarget 9.11 (2018): 9852.
Pubmed: 29515775 DOI: 10.18632/oncotarget.23955

Schizophrenia patients' cortexs exhibit variable expression of many genes, suggesting the involvement of transcription-controlling factors in general. In order to synchronize context-dependent alterations in gene expression, hormone nuclear receptors dimerize.
Corley, Susan M., et al. "Transcriptomic analysis shows decreased cortical expression of NR4A1, NR4A2 and RXRB in schizophrenia and provides evidence for nuclear receptor dysregulation." PloS one 11.12 (2016): e0166944.
Pubmed: 27992436 DOI: 10.1371/journal.pone.0166944