mProX™ Human PRKCQ Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX448	Magic™ Human PKCθ(PRKCQ) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MyLa;HuT 78

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research;Inflammation Research;Digestive and Renal Research

Related Diseases

Inflammatory Bowel Disease 1; Gastrointestinal Stromal Tumor

Gene ID

Human:5588

UniProt ID

Human:Q04759

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCQ, also known as protein kinase C theta, has been studied in various contexts. In sepsis, PRKCQ is identified as one of the autophagy-related key genes, and its expression is associated with diagnostic and prognostic value. PRKCQ is also found to be associated with immune cell signatures in sepsis. In coronary artery disease, PRKCQ is differentially expressed and is associated with HDL metabolism and atherogenesis. In sepsis, PRKCQ is identified as an immune biomarker and is involved in the ceRNA network. In the context of asthma, PRKCQ is involved in the IL-4/STAT6 signaling pathway and is targeted by black ginseng extract for its potentially anti-asthmatic activity. Additionally, PRKCQ is involved in apoptotic pathways and its proteolytically activated form is subject to N-degron-mediated degradation, which affects its pro-apoptotic function. These studies highlight the diverse applications of PRKCQ in various disease contexts, including sepsis, coronary artery disease, asthma, and apoptosis.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Smith (Verified Customer)

What is the role of PRKCQ in regulating immune-related lncRNAs in human gingival fibroblasts? Dec 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKCQ-AS1 and EGOT, as immune-related lncRNAs, regulate the expression of IL-1β, IL-6, and IL-8 in human gingival fibroblasts through the NF-κB pathway. Dec 15 2021

chat Casey Davis (Verified Customer)

How does PRKCQ influence chemotherapy sensitivity in triple-negative breast cancer? Nov 18 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibition of PRKCQ enhances chemosensitivity in triple-negative breast cancer by regulating Bim and the epithelial-mesenchymal transition. Nov 18 2022

Published Data

Fig.1 Impaired cell proliferation was observed in MyLa and HuT 78 cells due to PKCθ deficiency.

Following PRKCQ knockdown induction, an increase in cell proliferation was observed in MyLa and HuT 78 cells, with a sample size of n = 4.

Ref: García-Díaz, Nuria, et al. "PLCγ1/PKCθ downstream signaling controls cutaneous T-cell lymphoma development and progression." Journal of Investigative Dermatology 142.5 (2022): 1391-1400.

Pubmed: 34687742

DOI: 10.1016/j.jid.2021.09.024

Research Highlights

Yang, Li. et al. "Diagnostic and prognostic value of autophagy-related key genes in sepsis and potential correlation with immune cell signatures." Frontiers in cell and developmental biology, 2023.
This article describes a study that investigates the relationship between social media use and self-esteem among college students. Data was collected from a sample of 100 students through online surveys and analyzed through statistical analysis. Results showed a positive correlation between social media use and self-esteem, suggesting that increased social media use may contribute to higher levels of self-esteem in this population. These findings have implications for the understanding of the impact of social media on self-perception and self-worth, particularly in young adults.
Yang, Li. et al. "Diagnostic and prognostic value of autophagy-related key genes in sepsis and potential correlation with immune cell signatures." Frontiers in cell and developmental biology, 2023.
Pubmed: 37701780 DOI: 10.3389/fcell.2023.1218379

D Dergunov, Alexander. et al. "Differential Expression of Subsets of Genes Related to HDL Metabolism and Atherogenesis in the Peripheral Blood in Coronary Artery Disease." Current issues in molecular biology, 2023.
The researchers investigated the correlation between high-density lipoprotein cholesterol (HDL-C) and differential gene expression (DEGs) in coronary artery disease (CAD) in 76 male CAD patients and 63 control patients. RNA isolated from peripheral blood mononuclear cells was used to measure the transcript level of 24 genes related to HDL metabolism and 41 genes related to atherosclerosis-prone. Real-time RT-PCR identified 28 DEGs, and a significant downregulation of cholesterol transporters such as APOA1, ABCA1, and ABCG1 was found in CAD patients.
D Dergunov, Alexander. et al. "Differential Expression of Subsets of Genes Related to HDL Metabolism and Atherogenesis in the Peripheral Blood in Coronary Artery Disease." Current issues in molecular biology, 2023.
Pubmed: 37623250 DOI: 10.3390/cimb45080431