mProX™ Human PRKCB Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 In MKN-45 Cells, PRKCB was the downstream functional gene of hsa_circ_0092306/miR-197-3p.
Higher cell viability was observed in the PRKCB-overexpressed group, as indicated by the MTT assay. This increase in cell viability was found to be reversible when hsa_circ_0092306 was knocked down or miR-197-3p was overexpressed.
Ref: Chen, Zihao, et al. "hsa_circ_0092306 targeting miR-197-3p promotes gastric cancer development by regulating PRKCB in MKN-45 cells." Molecular Therapy-Nucleic Acids 18 (2019): 617-626.
Pubmed: 31689616
DOI: 10.1016/j.omtn.2019.08.012
Research Highlights
Bhagar, R. et al. "Temporal effects on death by suicide: empirical evidence and possible molecular correlates." Discover mental health, 2023.
In this study, a connection between full moons and increased suicides was empirically analyzed using pre-COVID suicide data from the Marion County Coroner's Office (n = 776). It was found that deaths by suicide were significantly increased during the week of the full moon (p = 0.037), with a stronger effect observed among older individuals (age ≥ 55) (p = 0.019). The analysis also revealed that the hour of the day (3-4 pm, p = 0.035) and the month of the year (September, p = 0.09) with the highest suicide rates were identified. Blood samples from a subset of subjects (n = 45) allowed for an examination of potential molecular mechanisms, revealing that certain blood biomarkers associated with suicidality were enriched in circadian clock genes during specific periods. These findings suggest temporal effects on suicidality, possibly influenced by biological clocks, highlighting the potential for therapeutic interventions related to ambient light, timing, and intensity to reduce suicide rates, in conjunction with psychiatric and addiction treatment approaches.
Bhagar, R. et al. "Temporal effects on death by suicide: empirical evidence and possible molecular correlates." Discover mental health, 2023.
Pubmed:
37861857
DOI:
10.1007/s44192-023-00035-4
Yu, Chenyang. et al. "Exploration of potential targets and mechanisms of naringenin in the treatment of nonalcoholic fatty liver disease through network pharmacology." Medicine, 2023.
The present study sought to utilize network pharmacology to examine the molecular pathways and potential targets involved in the treatment of nonalcoholic fatty liver disease (NAFLD) with naringenin (NR). By identifying novel targets and potential mechanisms, this research aims to provide new insights and possibilities for the development of NR as a therapeutic agent for NAFLD.
Yu, Chenyang. et al. "Exploration of potential targets and mechanisms of naringenin in the treatment of nonalcoholic fatty liver disease through network pharmacology." Medicine, 2023.
Pubmed:
37861538
DOI:
10.1097/MD.0000000000035460