mProX™ Human P2RX3 Stable Cell Line

N Bhebhe, Charity. et al. "KV7 but not dual small and intermediate KCa channel openers inhibit the activation of colonic afferents by noxious stimuli." American journal of physiology. Gastrointestinal and liver physiology, 2023.
Small and intermediate conductance Ca2+-activated K+ channels are widely distributed in various subtypes of both central and peripheral neurons. These channels play a crucial role in regulating neuronal excitability and synaptic transmission. Studies have shown that these channels are involved in the maintenance of action potential duration and in the modulation of neurotransmitter release. Furthermore, their dysregulation has been linked to various neurological disorders. Therefore, understanding the function and regulation of these channels is of great importance in the field of neuroscience.
N Bhebhe, Charity. et al. "KV7 but not dual small and intermediate KCa channel openers inhibit the activation of colonic afferents by noxious stimuli." American journal of physiology. Gastrointestinal and liver physiology, 2023.
Pubmed: 37667839   DOI: 10.1152/ajpgi.00141.2023

Marongiu, Michele. et al. "GWAS of genetic factors affecting white blood cell morphological parameters in Sardinians uncovers influence of chromosome 11 innate immunity gene cluster on eosinophil morphology." Human molecular genetics, 2023.
A limited number of genome-wide association studies (GWAS) investigating the genetic regulation of white blood cell morphological traits have been documented. In a study involving 869 individuals from the general population of Sardinia, Italy, researchers conducted a GWAS on 12 morphological traits within four white blood cell populations. This analysis identified seven statistically significant signals, including four previously undiscovered signals (PRG2, P2RX3, and two from CDK6). Five signals were confirmed in an independent INTERVAL cohort of 11,822 individuals. Notably, a prominent signal affecting eosinophil scatter was found within the innate immunity cluster on chromosome 11, residing in the PRG2 gene, with a substantial effect size. Computational analysis uncovered a rare Sardinian-specific PRG2:p.Ser148Pro mutation that potentially alters protein dynamics, offering insights into eosinophil morphology genetics, particularly in the Sardinian population. These findings provide novel insights into the genetic basis of morphological traits.
Marongiu, Michele. et al. "GWAS of genetic factors affecting white blood cell morphological parameters in Sardinians uncovers influence of chromosome 11 innate immunity gene cluster on eosinophil morphology." Human molecular genetics, 2023.
Pubmed: 36136759   DOI: 10.1093/hmg/ddac238