mProX™ Human MOS Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1227	Magic™ Human MOS in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HCT116

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research

Related Diseases

Oocyte/Zygote/Embryo Maturation Arrest 20; Sarcoma

Gene ID

Human:4342

UniProt ID

Human:P00540

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MOS (Molybdenum Disulfide) has various applications across different fields. In the medical field, a study protocol is being conducted to evaluate the efficacy and safety of Kami Guibi-tang (KGT), a herbal prescription used for insomnia and related conditions in older adults. In the field of catalysis, MOS is being utilized in the synthesis of a heterojunction hydrogel to enhance catalytic activation for the degradation of organic pollutants. In the field of sensor technology, MOS-based materials are being used to create neuro-inspired optical sensors for high-accuracy image recognition and trace extraction. Additionally, MOS is being utilized as a catalyst for the photothermal conversion of lignocellulosic biomass into hydrogen fuel. These applications demonstrate the versatility and potential of MOS in various scientific and technological fields.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Miller (Verified Customer)

How does Mos influence meiotic processes? Jul 28 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Mos, the c-mos protooncogene product, is a central regulator of meiosis in vertebrate oocytes and can force the mitotic cell cycle to undergo meiosis II. Jul 28 2021

chat Skyler Garcia (Verified Customer)

What is the oncogenic potential of Mos in somatic cells? May 01 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

When expressed ectopically, Mos can induce oncogenic transformation in somatic cells, affecting cell cycle progression and meiotic maturation. May 01 2022

Published Data

Fig.1 Overexpression of Mos causes genomic instability in stable tetraploid cells.

Stable p53-deficient HCT 116 cells were transfected with a polycistronic plasmid expressing green fluorescent protein (GFP) alone or co-expressing Mos and GFP for 48 hours. The GFP-positive populations were purified using fluorescence-activated cell sorting (FACS), cultured for 48 hours, and subsequently subjected to repetitive transfections with the same constructs at approximately 5-day intervals. The columns represent the percentage of sub-tetraploid cells (mean±s.e.m., n=3 independent experiments) as determined after single (I) or multiple (II, III) rounds of transfection.

Ref: Vitale, Ilio, et al. "Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos." The EMBO journal 29.7 (2010): 1272-1284.

Pubmed: 20186124

DOI: 10.1038/emboj.2010.11

Research Highlights

Liu, Qing-Yu. et al. "Solar-Driven Photothermal Catalytic Lignocellulosic Biomass-to-H2 Conversion." ACS applied materials & interfaces, 2023.
An effective conversion strategy is crucial for achieving sustainable use of lignocellulosic biomass, a promising source of chemical fuel. However, such strategies have been limited due to existing challenges. In this study, a novel approach involving photothermal catalysis using MoS2 and CeO2 was proposed for the selective conversion of lignocellulosic biomass. Results showed the potential of this method in overcoming the limitations of traditional conversion methods. This approach could significantly contribute to the sustainable utilization of lignocellulosic biomass.
Liu, Qing-Yu. et al. "Solar-Driven Photothermal Catalytic Lignocellulosic Biomass-to-H2 Conversion." ACS applied materials & interfaces, 2023.
Pubmed: 37871167 DOI: 10.1021/acsami.3c11091

Jiao, Guangzhong et al. "MOS mutation causes female infertility with large polar body oocytes." Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 38,12 (2022): 1158-1163.
The Moloney sarcoma oncogene (MOS) is known to encode a serine/threonine kinase protein and is highly expressed in oocytes undergoing meiotic maturation. This pathway, MOS/MAPK, typically plays a crucial role in maintaining the metaphasic state of microtubules and chromatin during meiotic divisions. To investigate the genetic factors behind female infertility linked to large polar body oocytes, the researchers conducted whole-exome sequencing on the patient and their family members, uncovering a previously unidentified homozygous missense mutation (c.591T> G) in MOS. Bioinformatics analysis confirmed the deleterious nature of this mutation, implicating it in the development of oocytes with large polar bodies and compromised embryonic development. Furthermore, it was suggested that the MOS variant might influence oocyte asymmetric division via the MAPK/WAVE2/Arp2/3/actin signaling pathway, shedding light on its role in early human reproductive processes and offering potential genetic markers for personalized genetic counseling and treatments.
Jiao, Guangzhong et al. "MOS mutation causes female infertility with large polar body oocytes." Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 38,12 (2022): 1158-1163.
Pubmed: 36403623 DOI: 10.1080/09513590.2022.2147158