mProX™ Human ESRRA Stable Cell Line

Product Information

Target Protein

ESRRA

Target Family

Estrogen-related Receptor

Target Protein Species

Human

Host Cell Type

SCC084; SCC131; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Cancer Research; Reproductive Research

Related Diseases

Breast Lobular Carcinoma; Endometrial Cancer

Gene ID

2101

UniProt ID

P11474

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ESRRA gene in humans encodes the nuclear receptor known as estrogen-related receptor alpha (ERRα), or NR3B1. ERRα is currently regarded as an orphan nuclear receptor. Although ERRα is widely distributed across tissues, it is most highly expressed in organs such the kidney, heart, brain, gut, brown adipose tissue, and skeletal muscle that preferentially use fatty acids as energy sources. Recently, ERRα has been found in normal tissues of the adrenal cortex; its expression may be associated with the development of the adrenals and may have a role in the function of the adrenals in fetal development, in the generation of DHEAS during adrenarche, and in the production of steroids throughout post-adrenarche and adult life. The customized ESRRA stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Charles (Verified Customer)

What's the significance of ESRRA mutation? Jun 04 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

ESRRA is an orphan nuclear receptor enriched in metabolically active tissues and has been known to affect the transcription of a set of genes that regulate mitochondrial bioenergetics in peripheral organs Jun 04 2022

chat Emily (Verified Customer)

What are other names for ESRRA? Mar 02 2023

chat Sherry Smith (Creative Biolabs Scientific Support)

This target may also be called "ERR1, ERRa, ESRL1, NR3B1, ERRalpha" in publications. Mar 02 2023

Published Data

Fig.1 Genomic amplification and expression of ESRRA in OSCC cell lines.

Four copies of ESRRA were present in the SCC084 and SCC131 cell lines, respectively. In both cell lines, the amount of ESRRA protein was higher than in the normal oral tissue from patient #63.

Ref: Tiwari, Ankana, et al. "Genomic amplification upregulates estrogen-related receptor alpha and its depletion inhibits oral squamous cell carcinoma tumors in vivo." Scientific Reports 5.1 (2015): 17621.

Pubmed: 26639757

DOI: 10.1038/srep17621

Research Highlights

Estrogen-related receptor α, also known as the orphan nuclear receptor, is a crucial modulator of mitochondrial activity and energy homeostasis. An essential innate effector against intracellular microorganisms is macroautophagy/autophagy, an intracellular breakdown process.
Kim, Soo Yeon, et al. "ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense." Autophagy 14.1 (2018): 152-168.
Pubmed: 28841353 DOI: 10.1080/15548627.2017.1339001

According to immunohistochemistry and transcriptome profiling, TN-ILC is a distinct aggressive breast cancer that is linked to advanced age and belongs to the luminal androgen receptor subtype. Additionally, it carries certain molecular changes (PI3K, ERBB2, and ESRRA) that could lead to the development of novel targeted treatment approaches.
Bergeron, Anthony, et al. "Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations." Modern Pathology 34.7 (2021): 1282-1296.
Pubmed: 33753865 DOI: 10.1038/s41379-021-00742-9